Accelerating Medical Innovation

Transforming Healthcare Through Innovative Medical Devices

Overview

InnoTree is an incubator and accelerator focused on medical devices, digital health and diagnostic companies. Our team brings extensive experience and strong expertise to manage every phase of product development and commercialization.

Our mission is to enhance patients' lives by accelerating the growth of innovative companies that are transforming the healthcare system.

Vision

We envision a world where the innovative potential of every physician and healthcare professional is fully realized, no longer constrained by bureaucratic, technical or financial barriers. InnoTree acts as the catalyst that elevates clinical ingenuity to a new dimension, transforming it into products that shape the future of medicine.

We believe that true breakthroughs do not emerge from isolated laboratories, but from the meeting of frontline clinical experience and managerial excellence. Our goal is to create an ecosystem of sustainable and unprecedented innovation, where every device we incubate is more than a product: it is proof that collaboration between visionaries and pragmatists can redefine standards of care, saving and improving countless lives.

Mission

Our Mission is to bring physicians' clinical insights to life, transforming them into innovative and accessible medical devices. As an incubator of excellence, we combine the clinical expertise and creativity of healthcare professionals with our deep managerial and scientific knowledge.

We support physicians at every stage of development: from initial idea validation through design, production, and market launch. Our objective is to break down traditional barriers and accelerate the creation of devices that not only enhance patients' quality of life but also optimize medical procedures.

Driven by a passion for innovation and strong management capabilities, we translate research and development into tangible, scalable results. We aim to be the bridge that connects clinical genius with engineering expertise and entrepreneurial vision, redefining the future of medicine.

What We Do

Idea Selection

We scout, assess and validate promising ideas and technologies in the medical field, estimating market size and evaluating feasibility, clinical impact and patient benefit.

Incubation and Acceleration

We provide a nurturing environment for medical technology startups, guiding them from concepts to market launch across the entire product lifecycle.

Development and Prototyping

InnoTree supports startups in transforming concepts into functional prototypes, collaborating with experts to refine designs and ensure safety and efficacy.

Startup Creation

We assist in establishing new companies, offering mentorship, legal guidance and business development support.

Fundraising

Raising capitals is critical for startups. InnoTree connects companies with investors, venture capitalists and strategic partners to secure funding.

InnoTree Funnel

1

Product concept with KOL (Key Opinion Leaders) support and pre-clinical validation

2

R&D and prototyping

3

Process development

4

Regulatory and Clinical strategy

5

Financial services

6

Strategic and legal planning

7

Product development and Supply Chain management

8

Product commercialization (Global Sales & Marketing)

Collaborations/Partnership

InnoTree collaborates with leading players across the medical technology innovation ecosystem. We are part of a research, innovation and financial network that accelerates solutions addressing health security challenges. Through our accelerator program, we support selected companies with tailored commercialization strategies.

Ongoing Project

Fluid dynamic visualization: optimized perfusion

Reinventing Mechanical Circulatory Support

Innovative solutions for the treatment of cardiogenic shock and high risk PCI.

InnoTree is developing a next-generation circulatory support technology designed to address the unmet clinical needs between conventional intra-aortic balloon pumps and more complex mechanical support systems. This innovative, balloon- and gas-free hemodynamic support system utilizes counter-phasic retrograde blood flow to support patients with heart failure.

The Clinical Need

A Critical Challenge in Cardiovascular Care

Cardiogenic shock remains one of the most severe cardiovascular emergencies, with significant mortality despite advances in modern medicine.

Current mechanical circulatory support options often require clinicians to balance effectiveness, complexity, invasiveness, and cost.

There is a growing need for innovative solutions capable of expanding access to advanced circulatory support while maintaining clinical practicality and economic sustainability.

Our Vision

Bridging the Gap

At InnoTree, we believe that the next generation of circulatory support should be:

  • Effective and clinically meaningful
  • Minimally invasive
  • Accessible to a broader range of hospitals
  • Simple to adopt and deploy
  • Designed around real-world clinical workflows

Our mission is to contribute to improved patient outcomes by developing advanced technologies that support clinicians in the management of acute cardiovascular conditions.

Scientific Approach

From Research to Clinical Innovation

The project combines expertise in:

  • Cardiovascular medicine
  • Biomedical engineering
  • Hemodynamic modeling
  • Medical device development
  • Regulatory and clinical validation

Development activities include computational simulations, laboratory testing, preclinical validation, and preparation for future clinical studies.

Scientific & Development Network

A Multidisciplinary Ecosystem for Innovation

The development of InnoTree's technology is driven by a multidisciplinary network of clinicians, biomedical engineers, researchers, and industrial partners working together to address one of the most challenging conditions in cardiovascular medicine.

The project benefits from collaborations with leading Italian institutions, including:

  • University of Brescia
  • Politecnico di Milano
  • Centro Cardiologico Monzino
  • IZSLER (Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna)

These organizations contribute expertise spanning cardiovascular medicine, biomedical engineering, computational modeling, preclinical research, translational science, and medical device development.

Alongside academic and clinical partners, the project is supported by a network of highly specialized Lombardy-based SMEs, providing advanced competencies in:

  • biomedical prototyping
  • engineering design
  • manufacturing technologies
  • testing and validation
  • regulatory support
  • industrial development

The combination of scientific excellence, clinical expertise, and industrial know-how creates a strong foundation for transforming innovative concepts into future healthcare solutions.

Investment & Partnership Opportunities

Building the Future Together

InnoTree is currently engaging with institutional and private investors to support the next phases of technology development and validation.

We welcome discussions with:

  • Strategic investors
  • Venture capital funds
  • Corporate partners
  • Medical device companies
  • Clinical research organizations
  • Healthcare institutions

We believe collaboration is essential to accelerate innovation and bring transformative technologies to patients.

Contact

Let's Connect

Whether you are a clinician, researcher, industrial partner, or investor, we would be pleased to discuss potential collaboration opportunities.

info@innotree.eu

Physiological principle: enhanced coronary perfusion, reduced afterload and ventricular unloading

Start-up Innovativa

Informazioni ai sensi dell'art. 25, commi 11 e 12, D.L. 179/2012 (conv. L. 221/2012)

Ultimo aggiornamento: 25.09.2026

INNOTREE S.R.L. è iscritta nella sezione speciale del Registro delle Imprese di Milano Monza Brianza Lodi dedicata alle start-up innovative dal 22/09/2026.

a) Costituzione

Data atto di costituzione08/09/2025
Luogo e notaioMilano, Studio Gasparro Frattini e Associati
Iscrizione Registro ImpreseSezione ordinaria dal 03/12/2025 · sezione speciale start-up innovative dal 22/09/2026

b) Sede

Sede legale: Via della Resistenza 121/B, 20090 Buccinasco (MI). Nessuna sede secondaria.

c) Oggetto sociale

Sviluppo, produzione e commercializzazione di prodotti e servizi innovativi ad alto valore tecnologico, in particolare: ricerca e sviluppo sperimentale nel campo dei dispositivi medici e delle tecnologie biomedicali; progettazione, prototipazione, validazione preclinica e clinica e produzione, anche tramite terzi, di dispositivi medici; sviluppo di software e sistemi di intelligenza artificiale in ambito sanitario; generazione e valorizzazione di privative industriali; conduzione di progetti di ricerca industriale e sviluppo sperimentale in collaborazione con università, IRCCS e centri di ricerca; servizi tecnico-scientifici connessi.

(Sintesi; il testo integrale è riportato nello statuto depositato presso il Registro Imprese, atto del 07/09/2026.)

d) Attività svolta e spese in ricerca e sviluppo

La società svolge attività di ricerca e sviluppo nel settore dei dispositivi medici cardiovascolari, con particolare riferimento a un nuovo sistema di contropulsazione per il supporto temporaneo della funzione cardiocircolatoria, attualmente in fase di ricerca, prototipazione e verifica sperimentale, non ancora destinato alla commercializzazione né all'utilizzo clinico.

Codice ATECO 202572.10.29 – Ricerca e sviluppo sperimentale (altre scienze naturali e ingegneria)
Spese in R&S – esercizio 2025Si attesta che nel corso dell'esercizio non sono stati sostenuti costi per attività di ricerca e sviluppo

e) Soci

SocioQuota nominale (€)%Diritto
CGA S.R.L. (C.F. 11066760965)4.125,0027,5%Proprietà
Fabio Barletta4.125,0027,5%Proprietà
Emanuele Meliga2.625,0017,5%Proprietà
Fabrizio Bertoli2.625,0017,5%Proprietà
Fabio Sabbione1.500,0010,0%Proprietà
Totale capitale sociale15.000,00100%

Tra i soci non figurano società fiduciarie né holding.

f) Società partecipate

Nessuna.

g) Titoli di studio ed esperienze professionali di soci e personale

NominativoTitoli ed esperienze
Fabio SabbioneLaurea in Economia aziendale (Università di Pavia); Executive MBA (Politecnico di Milano). Amministratore unico.
Fabrizio BertoliLaurea in Tecniche sanitarie (Università di Chieti).
Emanuele MeligaLaurea in Medicina (Università di Torino).
Fabio BarlettaDiploma.
Giorgio SemDiploma.

h) Relazioni con incubatori, investitori istituzionali, università e centri di ricerca

Nessuna.

i) Ultimo bilancio depositato

Bilancio al 31/12/2025, depositato presso il Registro Imprese.

l) Privative industriali

TitoloDomanda n.DepositoTitolare
Catetere di contropulsazione migliorato10202500003378417/12/2025INNOTREE S.R.L.

Join Us

If you are a healthcare professional or a medical-device startup with a transformative idea, consider joining InnoTree. Together we can create innovations that benefit patients and deliver lasting improvements in healthcare value.

Meet Our Team

Fabio Sabbione

Fabio Sabbione

CEO & CO-FOUNDER

Expert in launching new therapies and driving business growth in the structural heart field. He has worked in four start-ups, three acquired by multinational companies. Covering technical, clinical, commercial roles and supporting market development across multiple countries.

Emanuele Meliga

Emanuele Meliga

CO-Founder

Interventional Cardiologist with extensive experience in complex coronary and structural heart procedures. Member of the ESC Task Force for ACS and co-author of the 2020 ESC Guidelines for NSTE-ACS, he has published widely and contributed as a clinical trialist to the development of innovative cardiovascular therapies.

Fabrizio Bertoli

Fabrizio Bertoli

COO & Co-Founder

Executive with more than 20 years of international experience in medical device development and strategic management. He has led teams in bringing innovative technologies to market, combining product strategy, operational leadership, and deep expertise in healthcare innovation.

Christian Sem

Christian Sem

CFO & Co-Founder

Entrepreneur and CEO with broad experience in business development, organisational leadership and investment strategy across industries of the medical sector. He has supported international growth initiatives and participated in major exits as an investor, focusing on scalable models and sustainable value creation.

Fabio Barletta

Fabio Barletta

CFO & Co-Founder

Entrepreneur and CEO in the medical device industry for over 18 years, with collaborations with leading multinationals such as Cordis (J&J), Siemens, and Philips. He has introduced numerous innovative start-ups to the market and has strong expertise in business development, international expansion and strategic commercial operations.

Contact

info@innotree.eu